Zambrowicz, Brian: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

1

LX4211 Therapy Reduces Postprandial Glucose Levels in Patients With Type 2 Diabetes Mellitus and Renal Impairment Despite Low Urinary Glucose Excretion

Zambrowicz, Brian, Lapuerta, Pablo, Strumph, Paul, Banks, Phillip, Wilson, Alan, Ogbaa, Ike, Sands, Arthur, Powell, David

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 366 KB

english, 2015

2

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Kim, Jinrang, Okamoto, Haruka, Huang, ZhiJiang, Anguiano, Guillermo, Chen, Shiuhwei, Liu, Qing, Cavino, Katie, Xin, Yurong, Na, Erqian, Hamid, Rachid, Lee, Joseph, Zambrowicz, Brian, Unger, Roger, Mur

Journal:

Cell Metabolism

Year:

2017

Language:

english

File:

PDF, 5.03 MB

english, 2017

3

Tu1468 Lx1033, a Serotonin Synthesis Inhibitor (SSI), Decreases Levels of Urinary 5-HIAA: Results of a Phase 1 Study

Law, Linda, Ogbaa, Ike, Banks, Phillip, Jackson, Jessica, Frazier, Kenneth, Wilson, Alan G., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 84 KB

english, 2012

4

Sodium–Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport

Mudaliar, Sunder, Polidori, David, Zambrowicz, Brian, Henry, Robert R.

Journal:

Year:

2015

Language:

english

File:

PDF, 996 KB

english, 2015

5

Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation

Kim, Janice J., Wang, Huaqing, Terc, Joshua D., Zambrowicz, Brian, Yang, Qi M., Khan, Waliul I.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2015

Language:

english

File:

PDF, 2.95 MB

english, 2015

6

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes

Brommage, Robert, Liu, Jeff, Hansen, Gwenn M, Kirkpatrick, Laura L, Potter, David G, Sands, Arthur T, Zambrowicz, Brian, Powell, David R, Vogel, Peter

Journal:

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

7

Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry

Brian P Zambrowicz, C Alexander Turner, Arthur T Sands

Journal:

Current Opinion in Pharmacology

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

8

Study Design and Rationale of a Dose-Ranging Trial of LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy

Lapuerta, Pablo, Rosenstock, Julio, Zambrowicz, Brian, Powell, David R., Ogbaa, Ike, Freiman, Joel, Cefalu, William T., Banks, Phillip, Frazier, Kenny, Kelly, Mike, Sands, Arthur

Journal:

Clinical Cardiology

Year:

2013

Language:

english

File:

PDF, 128 KB

english, 2013

9

Severe Retinal Degeneration Associated with Disruption of Semaphorin 4A

Rice, Dennis S., Huang, Wenhu, Jones, Holly A., Hansen, Gwenn, Ye, Gui-Lan, Xu, Nianha, Wilson, Elizabeth A., Troughton, Kathy, Vaddi, Kris, Newton, Robert C., Zambrowicz, Brian P., Sands, Arthur T.

Journal:

Investigative Ophthalmology & Visual Science

Year:

2004

Language:

english

File:

PDF, 1.20 MB

english, 2004

10

Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity

Kleiner, Sandra, Gomez, Daniel, Megra, Bezawit, Na, Erqian, Bhavsar, Ramandeep, Cavino, Katie, Xin, Yurong, Rojas, Jose, Dominguez-Gutierrez, Giselle, Zambrowicz, Brian, Carrat, Gaelle, Chabosseau, Pa

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.56 MB

english, 2018

11

Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria With LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Patients With Type 2 Diabetes on Metformin Monotherapy

Rosenstock, Julio, Cefalu, William T., Lapuerta, Pablo, Zambrowicz, Brian, Ogbaa, Ike, Banks, Phillip, Sands, Arthur

Journal:

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

12

Telotristat Etiprate for Carcinoid Syndrome: A Single-Arm, Multicenter Trial

Pavel, Marianne, Hörsch, Dieter, Caplin, Martyn, Ramage, John, Seufferlein, Thomas, Valle, Juan, Banks, Phillip, Lapuerta, Pablo, Sands, Arthur, Zambrowicz, Brian, Fleming, Douglas, Wiedenmann, Bertra

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2015

Language:

english

File:

PDF, 423 KB

english, 2015

13

Telotristat etiprate, a novel inhibitor of serotonin synthesis for the treatment of carcinoid syndrome

Lapuerta, Pablo, Zambrowicz, Brian, Fleming, Doug, Wheeler, Darren, Sands, Arthur

Journal:

Clinical Investigation

Year:

2015

Language:

english

File:

PDF, 1.33 MB

english, 2015

14

Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

Powell, David, Gay, Jason, Smith, Melinda, Wilganowski, Nathaniel, Harris, Angela, Holland, Autumn, Reyes, Maricela, Kirkham, Laura, Kirkpatrick, Laura, Zambrowicz, Brian, Hansen, Gwenn, Platt, Kennet

Journal:

Diabetes Metabolic Syndrome and Obesity Targets and Therapy

Year:

2016

Language:

english

File:

PDF, 3.48 MB

english, 2016

15

Tu1334 Fasting Plasma 5-Hydroxyindolacetic Acid (5-HIAA) Correlates With 24-Hour Urinary 5-HIAA; Evaluation of a Simpler Assessment of 5-HIAA

Wilson, Alan G., Ogbaa, Ike, Banks, Phillip, Jackson, Jessica, Frazier, Kenneth, Law, Linda, Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

16

Multifunctional Alleles: A novel method for the generation of “All-In-One” null and conditional alleles

Pefanis, Evangelos, Schoenherr, Christopher, Persaud, Trikaldarshi, Zhang, Yuhong, Golubov, Jacquelynn, Wang, Bei, Skokos, Dimitris, Zambrowicz, Brian, Murphy, Andrew J., Economides, Aris N.

Journal:

Year:

2019

File:

PDF, 3.15 MB

2019

17

907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS

Philip Brown, Dennis S. Riff, Jessica Jackson, Kenneth Frazier, Elaine Clark, Qi M. Yang, Wade Walke, Joel Freiman, Alan J. Main, Brian Zambrowicz, Arthur Sands

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

18

In vivo drug target discovery: identifying the best targets from the genome

D.Wade Walke, Chunsheng Han, Joseph Shaw, Elisabeth Wann, Brian Zambrowicz, Arthur Sands

Journal:

Current Opinion in Biotechnology

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

19

S1053 Serotonin Biomarker Levels Correlate With Clinical Response in Phase 2 Trial of LX1031, a Novel Serotonin Synthesis Inhibitor for Non-Constipating IBS

Brian Zambrowicz, Philip Brown, Jessica Jackson, Kenneth Frazier, Elaine Clark, Qi M. Yang, Wade Walke, Joel Freiman, David Powell, Alan J. Main, Arthur Sands

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 99 KB

english, 2010

20

Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model

Oravecz, Tamas, Jhaver, Kanchan, Yang, Qi M., Wilson, Alan G., Main, Alan J., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 178 KB

english, 2012

21

Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes

Zambrowicz, Brian, Ding, Zhi-Ming, Ogbaa, Ike, Frazier, Kenny, Banks, Phillip, Turnage, Anne, Freiman, Joel, Smith, Melinda, Ruff, Dennis, Sands, Arthur, Powell, David

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

22

Systolic blood pressure reductions with sotagliflozin (LX4211), a dual SGLT1 and SGLT2 inhibitor, are associated with reductions in urinary sodium excretion

Lapuerta, Pablo, Biran, Talia, Zambrowicz, Brian, Powell, David, Banks, Phillip, Sands, Arthur, Strumph, Paul, Franklin, Stanley S., Bakris., George L.

Journal:

Journal of the American Society of Hypertension

Year:

2015

Language:

english

File:

PDF, 375 KB

english, 2015

23

Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes

Powell, David, Doree, Deon, Jeter-Jones, Sabrina, Ding, Zhi-Ming, Zambrowicz, Brian, Sands, Arthur

Journal:

Diabetes Metabolic Syndrome and Obesity Targets and Therapy

Year:

2015

Language:

english

File:

PDF, 912 KB

english, 2015

24

Full-speed mammalian genetics: in vivo target validation in the drug discovery process

Alejandro Abuin, Kathleen H Holt, Kenneth A Platt, Arthur T Sands, Brian P Zambrowicz

Journal:

Trends in Biotechnology

Year:

2002

Language:

english

File:

PDF, 132 KB

english, 2002

25

Disruption of Overlapping Transcripts in the ROSA β geo 26 Gene Trap Strain Leads to Widespread Expression of β -Galactosidase in Mouse Embryos and Hematopoietic Cells

Brian P. Zambrowicz, Akira Imamoto, Steve Fiering, Leonard A. Herzenberg, William G. Kerr and Philippe Soriano

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.81 MB

english, 1997

26

Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies

Yang, Qi M., Yu, Wangsheng, Swaffield, Jonathan, Powell, David, Wilson, Alan G., Brommage, Robert, Yalamanchili, Padmaja, Heydorn, William, Main, Alan J., Zambrowicz, Brian

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

27

Molecular Embryology: Methods and Protocolsby Paul T. Sharpe; Ivor Mason

Review by: Brian Zambrowicz

Journal:

Quarterly Review of Biology

Year:

2000

Language:

english

File:

PDF, 83 KB

english, 2000

28

Target Validation in Drug Discovery || GENERATION OF TRANSGENIC ANIMALS

ZAMBROWICZ, BRIAN P.

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

29

10.1038/33423

Zambrowicz, Brian P., Friedrich, Glenn A., Buxton, Eric C., Lilleberg, Stan L., Person, Christophe, Sands, Arthur T.

Journal:

Year:

1998

Language:

english

File:

PDF, 298 KB

english, 1998

30

Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex

Hiroki Yoshino, Takeaki Miyamae, Gwenn Hansen, Brian Zambrowicz, Michael Flynn, Donna Pedicord, Yuval Blat, Ryan S. Westphal, Robert Zaczek, David A. Lewis, Guillermo Gonzalez-Burgos

Journal:

The Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

31

Crystallization and preliminary X-ray analysis of Escherichia coli adenylate kinase

Althoff, Steven, Zambrowicz, Brian, Liang, Peng, Glaser, Michael, Phillips, George N.

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 239 KB

english, 1988

32

Analysis of the Mouse Protamine 1 Promoter in Transgenic Mice

Brian P. Zambrowicz, Christopher J. Harendza, James W. Zimmermann, Ralph L. Brinster and Richard D. Palmiter

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.12 MB

english, 1993

33

Characterization of the Murine Zfy1 and Zfy2 Promoters

Brian P. Zambrowicz, Seth D. Finalley, Elizabeth M. Simpson, David C. Page, Richard D. Palmiter

Journal:

Year:

1994

File:

PDF, 155 KB

1994

34

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

Quaife, Carol J., Findley, Seth D., Erickson, Jay C., Froelick, Glenda J., Kelly, Edward J., Zambrowicz, Brian P., Palmiter, Richard D.

Journal:

Year:

1994

Language:

english

File:

PDF, 5.23 MB

english, 1994

35

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 44 Volume 44 || Chapter 23 A Path to Innovation: Gene Knockouts Model New Drug Action

Zambrowicz, Brian P.

Year:

2009

Language:

english

File:

PDF, 185 KB

english, 2009

36

Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice

SHIELS, ALAN, BASSNETT, STEVEN, VARADARAJ, KULANDAIAPPA, MATHIAS, RICHARD, AL-GHOUL, KRISTIN, KUSZAK, JER, DONOVIEL, DORIT, LILLEBERG, STAN, FRIEDRICH, GLENN, ZAMBROWICZ, BRIAN

Journal:

Physiological Genomics

Year:

2001

Language:

english

File:

PDF, 427 KB

english, 2001

37

Sa2017 Blocking Peripheral Serotonin Synthesis by Telotristat Etiprate Reduces the Severity of Both Chemical- and Infection-Induced Intestinal Inflammation

Kim, Janice J., Wang, Huaqing, Terc, Joshua D., Sunjic, Ivana, Zambrowicz, Brian, Yang, Qi M., Khan, Waliul I.

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

38

Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes

Powell, David, Doree, Deon, Jeter-Jones, Sabrina, Ding, Zhi-Ming, Zambrowicz, Brian, Sands, Arthur

Journal:

Diabetes Metabolic Syndrome and Obesity Targets and Therapy

Year:

2015

File:

PDF, 912 KB

2015

39

Knockouts model the 100 best-selling drugs—will they model the next 100?

Zambrowicz, Brian P., Sands, Arthur T.

Journal:

Nature Reviews Drug Discovery

Year:

2003

Language:

english

File:

PDF, 456 KB

english, 2003

40

Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes

Sands, Arthur T., Zambrowicz, Brian P., Rosenstock, Julio, Lapuerta, Pablo, Bode, Bruce W., Garg, Satish K., Buse, John B., Banks, Phillip, Heptulla, Rubina, Rendell, Marc, Cefalu, William T., Strumph

Journal:

Year:

2015

Language:

english

File:

PDF, 848 KB

english, 2015

41

The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome

Philip M. Brown, Douglas A. Drossman, Alastair J.J. Wood, Gary A. Cline, Kenny S. Frazier, Jessica I. Jackson, Johanna Bronner, Joel Freiman, Brian Zambrowicz, Arthur Sands, Michael D. Gershon

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 1.55 MB

english, 2011

42

Modeling drug action in the mouse with knockouts and RNA interference

Brian P. Zambrowicz, Arthur T. Sands

Journal:

Drug Discovery Today: TARGETS

Year:

2004

Language:

english

File:

PDF, 742 KB

english, 2004

43

Effects of LX4211, a Dual Sodium-Dependent Glucose Cotransporters 1 and 2 Inhibitor, on Postprandial Glucose, Insulin, Glucagon-like Peptide 1, and Peptide Tyrosine Tyrosine in a Dose-Timing Study in Healthy Subjects

Zambrowicz, Brian, Ogbaa, Ike, Frazier, Kenny, Banks, Phillip, Turnage, Anne, Freiman, Joel, Boehm, Kristi A., Ruff, Dennis, Powell, David, Sands, Arthur

Journal:

Clinical Therapeutics

Year:

2013

Language:

english

File:

PDF, 427 KB

english, 2013

To build up a library is to create a life. It’s never just a random collection of books.

— Carlos María Domínguez

Official channel

Z-Library Desktop Launcher

Z-Library Since 2009 support@1delivery.pm

EnglishРусскийEspañolItalianoελληνικάاللغة العربيةBahasa IndonesiaBahasa Malaysiaहिन्दीDeutschFrançaisPortuguêsУкраїнськаPolski中文繁體中文日本語Tiếng ViệtAzərbaycan DiliՀայոց լեզուภาษาไทยTürk Diliქართველიবাংলাپښتوతెలుగుاردو한국어SrpskiБългарски